Personalised Medicine in Endometrial Cancer Through the Use of Liquid Biopsy

Abstract

Although usually associated with good clinical outcome, endometrial cancer incidence and mortality has been rising over the past years. To tackle the different clinical challenges required to change this negative evolution, in the current doctoral thesis we studied minimally invasive samples such as the uterine aspirate and plasma samples to better understand the molecular characteristics of this tumour and to validate accurate prognostic and follow-up tools and new therapeutic targets. Moreover, we combined these tools with the development of patient derived preclinical models for personalized pharmacological studies. Overall, the results obtained in this thesis demonstrated the value of liquid-biopsybased pipelines to improve the management of localised and advanced endometrial cancer patients.