Tuning the properties of penetrating peptides by oxime conjugation

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorPazo Pascual, Marta
dc.contributor.authorFernández Caro, Héctor
dc.contributor.authorPriegue Caamaño, Juan Manuel
dc.contributor.authorLostalé Seijo, Irene
dc.contributor.authorMontenegro García, Javier
dc.date.accessioned2017-02-13T09:42:08Z
dc.date.available2017-02-13T09:42:08Z
dc.date.issued2017-01-25
dc.description.abstractWe here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating peptides. We believe that this approach will allow the development of improved intracellular delivery vehiclesgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy and Competitivity (MINECO) [CTQ2014-59646-R], the Xunta de Galicia (ED431G/09) and the ERDF. J.P. received an F.P.I. fellowship from MINECO. J.M. received a Ramon y Cajal (RYC-2013-13784) and an ERC Starting Investigator Grant (DYNAP-677786)gl
dc.identifier.citationMontenegro, Javier, Pazo, Marta, Fernández-Caro, Héctor, Priegue, Juan and Lostalé-Seijo, Irene, 2017, Tuning the Properties of Penetrating Peptides by Oxime Conjugation. Synlett. 2017. DOI 10.1055/s-0036-1588689. Thieme Publishing Groupgl
dc.identifier.doi10.1055/s-0036-1588689
dc.identifier.essn1437-2096
dc.identifier.issn0936-5214
dc.identifier.urihttp://hdl.handle.net/10347/15141
dc.language.isoenggl
dc.publisherGeorg Thieme Verlaggl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/677786
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-59646-R/ES/NUEVOS DISEÑOS CON CONTROL TOPOLOGICO DE PEPTIDOS PENETRANTES EN CELULAS
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13784/ES
dc.relation.publisherversionhttp://dx.doi.org/10.1055/s-0036-1588689gl
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Españagl
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectPeptide chemistrygl
dc.subjectPenetrating peptidesgl
dc.subjectSupramolecular chemistrygl
dc.subjectMembrane transportgl
dc.subjectSolid-phase peptide synthesisgl
dc.subject.classificationMaterias::Investigación::23 Química::2302 Bioquímicagl
dc.titleTuning the properties of penetrating peptides by oxime conjugationgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublicationb645ce32-31f3-4ca4-9e9f-c1324ff0717e
relation.isAuthorOfPublication.latestForDiscoveryb645ce32-31f3-4ca4-9e9f-c1324ff0717e

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