Pregnanetriolone in paper-borne urine for neonatal screening for 21-hydroxylase deficiency: The place of urine in neonatal screening

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatríagl
dc.contributor.authorAlonso Fernández, José Ramón
dc.date.accessioned2017-10-20T22:24:38Z
dc.date.available2017-10-20T22:24:38Z
dc.date.issued2016-08-18
dc.description.abstractThe standard method of primary neonatal screening for congenital adrenal hyperlasia (CAH), determination of 17-hydroxyprogesterone (17OHP) in heelprick blood, is the object of recurrent controversy because of its poor diagnostic and economic efficiency. The superior ability of urinary pregnanetriolone levels to discriminate between infants with and without classical CAH has been known for some time, but has not hitherto been exploited for primary screening. Here we propose an economical neonatal CAH-screening system based on fluorimetric determination of the product of reaction between urinary pregnanetriolone and phosphoric acidgl
dc.description.peerreviewedSIgl
dc.identifier.doi10.1016/j.ymgmr.2016.08.006
dc.identifier.issn2214-4269
dc.identifier.urihttp://hdl.handle.net/10347/15913
dc.language.isoenggl
dc.publisherElseviergl
dc.relation.publisherversionhttps://doi.org/10.1016/j.ymgmr.2016.08.006gl
dc.rights© 2016 The Author. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/gl
dc.rights.accessRightsopen accessgl
dc.subjectNewborn screeninggl
dc.subjectCongenital adrenal hyperplasia (CAH)gl
dc.subjectUrine sample on papergl
dc.subjectPregnanetriolonegl
dc.titlePregnanetriolone in paper-borne urine for neonatal screening for 21-hydroxylase deficiency: The place of urine in neonatal screeninggl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication

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