Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates

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URI: http://hdl.handle.net/10347/18486
ISSN: 1359-7345
E-ISSN: 1364-548X
DOI: 10.1039/C2CC34958B

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2012

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Royal Society of Chemistry
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The luminescence of a designed peptide equipped with a coordinatively-unsaturated lanthanide complex is modulated by the phosphorylation state of a serine residue in the sequence. While the phosphorylated state is weakly emissive, even in the presence of an external antenna, removal of the phosphate allows coordination of the sensitizer to the metal, yielding a highly emissive supramolecular complex

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Pazos, E., Goličnik, M., Mascareñas, J., & Eugenio Vázquez, M. (2012). Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates. Chemical Communications, 48(76), 9534. doi: 10.1039/c2cc34958b

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We thank the financial support provided by the Spanish grants SAF2010-20822-C02, CTQ2009-14431/BQU, CSD2007-00006, Consolider Ingenio 2010, the Xunta de Galicia GRC2010/12, INCITE09 209 084PR, PGIDIT08CSA-047209PR, Slovenian Research Agency (grant P1-170 to M.G.). E. P. thanks the Xunta de Galicia for her postdoctoral contract

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© The Royal Society of Chemistry 2012

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Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica