New strategies for the production of ready-to-implant bone scaffolds using supercritical fluid technology

Abstract

This PhD Thesis highlights the advantages of the supercritical CO2 technology for the preparation of sterile scaffolds for regenerative medicine applications. On the one hand, this technology allows the production of polymeric scaffolds in the absence of organic solvents and downstream processes. In addition, the extraction capacity of supercritical CO2 also allows the preparation of bio-based aerogels. On the other hand, the antimicrobial effect of supercritical CO2 can be exploited for the sterilization of thermosensitive materials, including biodegradable scaffolds.