Anion recognition and induced self-assembly of an alpha,gamma-cyclic peptide to form spherical clusters

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorRodríguez-Vázquez, Nuria
dc.contributor.authorAmorín López, Manuel
dc.contributor.authorGranja Guillán, Juan Ramón
dc.contributor.authorAlfonso, Ignacio
dc.date.accessioned2018-05-29T08:34:25Z
dc.date.available2018-05-29T08:34:25Z
dc.date.issued2016-03-21
dc.description.abstractA cyclic octapeptide composed of hydroxy-functionalized γ-amino acids folds in a "V-shaped" conformation that allows the selective recognition of anions such as chloride, nitrate, and carbonate. The process involves the simultaneous self-assembly of six peptide subunits and the recognition of four anions to form a tetrahedral structure, in which the anions are located at the corners of the resulting structure. Each anion is coordinated to three different peptides. The structure was fully characterized by several techniques, including NMR spectroscopy and X-ray diffraction, and the material was able to facilitate the transmembrane transport of chloride ionsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy and Competitivity (MINECO) and the ERDF [CTQ2013-43264-R, CTQ2012-38543-C03-03], and by the Xunta de Galicia and the ERDF (GPC2013-039 and EM2014/011). N. R.-V. thanks MINECO for her FPU contract. We also thank ORFEO-CINCA network and MINECO (CTQ2014-51912-REDC). Technical support from the Unidade de Raios X, RIADT, USC, and especially to Antonio L. Llamas-Saiz is gratefully acknowledgedgl
dc.identifier.citationRodríguez-Vázquez, N., García-Fandiño, R., Amorín, M., & Granja, J. (2016). Anion recognition self-assembly α,γ-cyclic peptide to form spherical clusters. Angewandte Chemie internationa edition,55(14):4504-8. Doi: 10.1002/anie.201511857gl
dc.identifier.doi10.1002/anie.201511857
dc.identifier.essn1521-3773
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/10347/16736
dc.language.isoenggl
dc.publisherWileygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-51912/ES/RED ORFEO-CINQA "CENTRO DE INNOVACION EN QUIMICA AVANZADA”
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-43264-R/ES/NUEVAS TERAPIAS SUPRAMOLECULARES DIRIGIDAS A LAS MEMBRANAS LIPIDICAS Y BASADAS EN NANOESTRUCTURAS AUTOENSAMBLADAS
dc.relation.publisherversionhttps://doi.org/10.1002/anie.201511857gl
dc.rights© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheimgl
dc.rights.accessRightsopen accessgl
dc.subjectAnionrecognitiongl
dc.subjectCyclic peptidegl
dc.subjectSelf-assemblinggl
dc.subjectSupramolecular chemistrygl
dc.subjectTransportgl
dc.subject.classificationMaterias::Investigación::23 Química::2306 Química orgánicagl
dc.titleAnion recognition and induced self-assembly of an alpha,gamma-cyclic peptide to form spherical clustersgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
relation.isAuthorOfPublication5c5f030f-17cc-4122-a603-7957ca9e0aab
relation.isAuthorOfPublicationfb6bbc55-1505-4e96-9863-825f7d16309c
relation.isAuthorOfPublication.latestForDiscovery5c5f030f-17cc-4122-a603-7957ca9e0aab

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