Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicasgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxíagl
dc.contributor.authorQuiñones Téllez, María del Mar
dc.contributor.authorMartínez Grobas, Eva
dc.contributor.authorFernø, Johan
dc.contributor.authorPérez Lois, Raquel
dc.contributor.authorSeoane, María Luisa
dc.contributor.authorAl-Massadi Iglesias, Omar
dc.date.accessioned2021-02-15T11:42:42Z
dc.date.available2021-02-15T11:42:42Z
dc.date.issued2021
dc.description.abstractSirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balancegl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work is supported by grants of Xunta de Galicia (MQ:2018-PG013). Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. Western Norway Regional Health Authority (Helse Vest RHF).M.Q. is a recipient of a Postdoctoral contract from Galician Government (Xunta de Galicia ED481B2018/004). O.A.M. was funded by a research contract Miguel Servet (CP20/00146) from the ISCIIIgl
dc.identifier.citationInt. J. Mol. Sci. 2021, 22(3), 1430; https://doi.org/10.3390/ijms22031430gl
dc.identifier.doi10.3390/ijms22031430
dc.identifier.essn1422-0067
dc.identifier.urihttp://hdl.handle.net/10347/24452
dc.language.isoenggl
dc.publisherMDPIgl
dc.relation.publisherversionhttps://doi.org/10.3390/ijms22031430gl
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)gl
dc.rightsAtribución 4.0 Internacional
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSIRT1gl
dc.subjectSIRT6gl
dc.subjectEnergy balancegl
dc.subjectFood intakegl
dc.subjectBody weightgl
dc.subjectAdipositygl
dc.subjectType 2 diabetesgl
dc.subjectObesitygl
dc.titleHypothalamic Actions of SIRT1 and SIRT6 on Energy Balancegl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublicationd843efb9-cd89-4f23-b395-4b51d1327dfc
relation.isAuthorOfPublication.latestForDiscoveryd843efb9-cd89-4f23-b395-4b51d1327dfc

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