Coumarin-Chalcone Hybrids as new scaffolds in drug discovery

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The first hydroxilated series of coumarin-chalcone derivatives has been synthesize starting from the corresponding salicyl aldehyde and β-ketoester precursors by a Knoevenagel reaction in order to obtain the methoxy derivatives which have been further hydrolyzed with a Lewis acid

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The 13th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

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Uriarte, E.; Santana, L.; Serra, S.; Vázquez Rodríguez, S. Coumarin-Chalcone Hybrids as new scaffolds in drug discovery, in Proceedings of the 13th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2009, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-13-00191

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© 2009 The author(s). Published by MDPI, Basel, Switzerland. Open Access