Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.authorComas, Laura
dc.contributor.authorPolo Tobajas, Ester
dc.contributor.authorDomingo, M. Pilar
dc.contributor.authorHernández, Yulán
dc.contributor.authorArias, Maykel
dc.contributor.authorEsteban, Patricia
dc.contributor.authorMartínez-Lostao, Luis
dc.contributor.authorPardo, Julián
dc.contributor.authorMartínez de la Fuente, Jesús
dc.contributor.authorGálvez, Eva M.
dc.date.accessioned2019-09-11T08:58:31Z
dc.date.available2019-09-11T08:58:31Z
dc.date.issued2019
dc.description.abstractGliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancergl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work was supported by Fondo Social Europeo (FSE; Gobierno de Aragón), ASPANOA and by grants SAF2017-83120-C2-1-R, SAF2014-54763-C2-1-R, SAF2014-54763-C2-2-R from Spanish Ministry of Economy and Competitivenes. LC was granted by a DGA predoctoral contract, EP by a Juan de la Cierva Incorporacion fellowship program (IJCI-2016-30706) and MA by a Juan de la Cierva Formación fellowship program (FJCI-2017-31629)gl
dc.identifier.citationComas, L.; Polo, E.; Domingo, M.P.; Hernández, Y.; Arias, M.; Esteban, P.; Martínez-Lostao, L.; Pardo, J.; Martínez de la Fuente, J.; Gálvez, E.M. Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles. Materials 2019, 12, 1092gl
dc.identifier.doi10.3390/ma12071092
dc.identifier.issn1996-1944
dc.identifier.urihttp://hdl.handle.net/10347/19757
dc.language.isoenggl
dc.publisherMDPIgl
dc.relation.publisherversionhttps://doi.org/10.3390/ma12071092gl
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)gl
dc.rightsAtribución 4.0 Internacional
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMagnetic nanoparticlesgl
dc.subjectGliotoxingl
dc.subjectTherapeuticgl
dc.subjectDrug deliverygl
dc.subjectCancer cellsgl
dc.titleIntracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticlesgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication8b9beb32-7cfc-4c41-871e-f0960dcb60e3
relation.isAuthorOfPublication.latestForDiscovery8b9beb32-7cfc-4c41-871e-f0960dcb60e3

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