Ruthenium-catalyzed intermolecular alkene–alkyne couplings in biologically relevant media

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculareses_ES
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicaes_ES
dc.contributor.authorGutiérrez González, Alejandro
dc.contributor.authorMarcos-Atanes, Daniel
dc.contributor.authorCool, Leonard G.
dc.contributor.authorLópez García, Fernando José
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2023-06-15T09:15:08Z
dc.date.available2023-06-15T09:15:08Z
dc.date.issued2023
dc.description.abstractCationic cyclopentadienyl Ru(II) catalysts can efficiently promote mild intermolecular alkyne–alkene couplings in aqueous media, even in the presence of different biomolecular components, and in complex media like DMEM. The method can also be used for the derivatization of amino acids and peptides, therefore proposing a new way to label biomolecules with external tags. This C–C bond-forming reaction, based on simple alkene and alkyne reactants, can now be added to the toolbox of bioorthogonal reactions promoted by transition metal catalystses_ES
dc.description.peerreviewedSIes_ES
dc.description.sponsorshipThis work has received financial support from Spanish grants (Grants PID2020-118579GB-I00 and PID2019-108624RB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, and ORFEO-CINQA network RED2018-102387-T), the Consellería de Cultura, Educación e Ordenación Universitaria (Grant ED431C 2021/25 and Grant ED431G 2019/03: Centro Singular de Investigación de Galicia accreditation 2019–2022) and the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014–2020). We thank the Ministerio de Universidades for the FPU fellowship to A. G. and D. M.-A. (FPU17/00711 and FPU18/04495)es_ES
dc.identifier.citationChem. Sci., 2023, 14, 6408es_ES
dc.identifier.doi10.1039/d3sc01254a
dc.identifier.essn1742-2183
dc.identifier.issn1478-6524
dc.identifier.urihttp://hdl.handle.net/10347/30683
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118579GB-I00/ESes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108624RB-I00/ES/HERRAMIENTAS BASADAS EN METALES PARA SU USO EN QUIMICA BIOLOGICA Y BIOMEDICINA. DESARROLLO DE NUEVAS ESTRATEGIAS ANTICANCERes_ES
dc.relation.publisherversionhttps://doi.org/10.1039/D3SC01254Aes_ES
dc.rights© 2023 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.es_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/legalcode
dc.titleRuthenium-catalyzed intermolecular alkene–alkyne couplings in biologically relevant mediaes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationfbcc313d-9cf6-48e4-b938-6430092aa8ae
relation.isAuthorOfPublication57da1b39-f2e1-4877-9965-de9833c59807
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery57da1b39-f2e1-4877-9965-de9833c59807

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