Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorGómez González, Jacobo
dc.contributor.authorMartínez Castro, Laura
dc.contributor.authorTolosa Barrilero, Juan
dc.contributor.authorAlcalde Ordóñez, Ana
dc.contributor.authorLearte Aymamí, Soraya
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorGarcía Martínez, Joaquín C.
dc.contributor.authorMartínez Costas, José Manuel
dc.contributor.authorMaréchal, Jean-Didier
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.date.accessioned2022-08-02T08:23:00Z
dc.date.issued2022
dc.description.abstractNon-canonical DNA structures, particularly 3-way junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene coregl
dc.description.embargo2023-07-18
dc.description.peerreviewedSIgl
dc.identifier.citationGomez-Gonzalez, J.; Martinez-Castro, L.; Tolosa-Barrilero, J.; Alcalde-Ordoñez, A.; LearteAymamí, S.; Mascareñas, J. L.; García-Martínez, J. C.; Martínez-Costas, J.; Maréchal, J.-D.; Vázquez López, M.; Vázquez, M. E. (2022), Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide. Chem. Commun., 58: 7769-7772. doi: 10.1039/D2CC02874Cgl
dc.identifier.doi10.1039/D2CC02874C
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/10347/28981
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.publisherversionhttps://doi.org/10.1039/D2CC02874Cgl
dc.rights© 2022 RSC. This article may be used for non-commercial purposes in accordance with the Royal Society of Chemistry Terms and Conditions for Use of Self-Archived Versionsgl
dc.rights.accessRightsopen accessgl
dc.titleSelective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptidegl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery811a1eac-4048-4ed9-a56f-c1104cc20827

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