Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

Simple item page
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorDestito, Paolo
dc.contributor.authorSousa Castillo, Ana
dc.contributor.authorRodríguez Couceiro, José
dc.contributor.authorLópez García, Fernando
dc.contributor.authorCorrea Duarte, Miguel Ángel
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-21T14:27:04Z
dc.date.available2019-03-21T14:27:04Z
dc.date.issued2019
dc.description.abstractWe describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki–Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cellsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work has received financial support from Spanish grants (SAF2016-76689-R, CTQ2017-84767-P, CTM2014-58481-R, CTM2017-84050-R and Orfeo-Cinqa network CTQ2016-81797- REDC), the Consellería de Cultura, Educación e Ordenación Universitaria (2015-CP082, ED431C/2017119 and Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/09), the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014–2020), and the European Research Council (Advanced Grant No. 340055)gl
dc.identifier.citationDestito, P., Sousa-Castillo, A., Couceiro, J., López, F., Correa-Duarte, M., & Mascareñas, J. (2019). Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media. Chemical Science, 10(9), 2598-2603. doi: 10.1039/c8sc04390fgl
dc.identifier.doi10.1039/c8sc04390f
dc.identifier.issn2041-6539
dc.identifier.urihttp://hdl.handle.net/10347/18462
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76689-R/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-84767-P/ES/METODOS SINTETICOS EFICIENTES BASADOS EN CATALISIS METALICA. DESARROLLOS ENANTIOSELECTIVOS Y ACCESO A MOLECULAS BIOACTIVAS Y/O DE ALTO INTERES SINTETICO
dc.relation.publisherversionhttps://doi.org/10.1039/C8SC04390Fgl
dc.rights© The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution 3.0 Unported Licencegl
dc.rights.accessRightsopen accessgl
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleHollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous mediagl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery5ae222c9-f626-432b-aac5-da78c06ed64f

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2019_chemsci_destito_hollow.pdf
Size:
2.32 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica